Methylphenidate hydrochloride solution
methylphenidate hydrochloride methanol*solution
CAS: 298-59-9
Molecular Formula: C14H20ClNO2
Methylphenidate hydrochloride solution - Names and Identifiers
| Name | methylphenidate hydrochloride methanol*solution |
| Synonyms | Methylphenidate HCl METHYLPHENIDATE HCL meridilhydrochloride RITALIN HYDROCHLORIDE Ritalin (Methylphenidate Hcl) Methylphenidate Hydrochloride METHYLPHENIDATE HYDROCHLORIDE Methylphenidate hydrochloride solution methylphenidate hydrochloride methanol*solution methyl (2R)-phenyl[(2S)-piperidin-2-yl]ethanoate 2-piperidineaceticacid,alpha-phenyl-,methylester,hydrochloride |
| CAS | 298-59-9 |
| EINECS | 206-065-3 |
| InChI | InChI=1/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13+/m0/s1 |
Methylphenidate hydrochloride solution - Physico-chemical Properties
| Molecular Formula | C14H20ClNO2 |
| Molar Mass | 269.77 |
| Density | 1.07g/cm3 |
| Melting Point | 196-198?C |
| Boling Point | 327.6°C at 760 mmHg |
| Flash Point | 9℃ |
| Solubility | Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| Vapor Presure | 0.000199mmHg at 25°C |
| pKa | 8.9(at 25℃) |
| Storage Condition | Store at RT |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates. |
| Refractive Index | 1.523 |
Methylphenidate hydrochloride solution - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R42 - May cause sensitization by inhalation R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | TM3850000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 190 mg/kg (Greenblatt, Osterberg) |
Methylphenidate hydrochloride solution - Standard
Authoritative Data Verified Data
This product is methyl a-phenyl -2-piperidine acetate hydrochloride. Calculated as dry product, containing no less than 98.0% of C14H19N02 • hc1.
Last Update：2024-01-02 23:10:35
Methylphenidate hydrochloride solution - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in water or methanol, soluble in ethanol, slightly soluble in chloroform, almost insoluble in acetone.
Last Update：2022-01-01 15:06:57
Methylphenidate hydrochloride solution - Differential diagnosis
Authoritative Data Verified Data
- take this product, add ethanol to dissolve and dilute to make about l per lml. The 0 mg solution has absorption maxima at wavelengths of 0401 nm, NM and NM, as determined by UV-Vis spectrophotometry (General rule 1).
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 374).
- This product is chloride identification reaction (General 0301).
Last Update：2022-01-01 15:06:57
Methylphenidate hydrochloride solution - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and dilute to make about 0.lg of the solution, as a test solution; Precision take the appropriate amount, quantitative dilution with methanol made per 1 ml containing l. 0 mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, draw 10ul of each of the above two solutions, respectively, on the same silica gel G thin layer plate, with chloroform-methanol-concentrated ammonia solution (19:1:0.1) as the developing solvent, expand, dry, spray with bismuth potassium iodide test solution, and immediately check. If the test solution shows impurity spots, the color should not be deeper compared with the main spots of the control solution.
loss on drying
take this product, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
This product l.Og, inspection according to law (General Principles 0821 The first law), containing heavy metals shall not exceed 10 parts per million.
Last Update：2022-01-01 15:06:58
Methylphenidate hydrochloride solution - Content determination
Authoritative Data Verified Data
take about 0.2g of this product, precision weighing, add 15ml of glacial acetic acid and 5ml of Mercury acetate test solution to dissolve, add 4 drops of naphthol benzyl alcohol indicator solution, and use perchloric acid titration solution (0.1 mol/L) titration to the solution is green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 26.98mg of C14H19N02. HCI.
Last Update：2022-01-01 15:06:59
Methylphenidate hydrochloride solution - Category
Authoritative Data Verified Data
psychostimulants.
Last Update：2022-01-01 15:06:59
Methylphenidate hydrochloride solution - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:06:59
Methylphenidate hydrochloride solution - Methylphenidate hydrochloride tablets
Authoritative Data Verified Data
This product contains methylphenidate hydrochloride (C14H19N02 • HCl) should be 90.0% ~ 110.0% of label amount.
trait
This product is white tablet.
identification
The filtrate obtained under the item of content determination was diluted with methanol to obtain about methylphenidate hydrochloride l per 1 ml. The solution of 0 mg showed the same results according to the test of identification (1) under the item of methylphenidate hydrochloride.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
take 60 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.25g equivalent to methylphenidate hydrochloride), put it in a 50ml measuring flask, add methanol 30ml, slightly warm, shake to dissolve methylphenidate hydrochloride, let it cool, dilute to scale with methanol, shake well, filter, take 20ml of the filtrate accurately, and then dry it on water bath, according to the method under the item of methylphenidate hydrochloride, the determination was carried out according to the law from "After 15ml of glacial acetic acid and 5ml of mercuric acetate solution were added for dissolution. Each 1 ml of high gas acid titrant (0.1 mol/L) corresponds to 26.98mg of C14H19N02. HCl.
category
with methylphenidate hydrochloride.
specification
lOmg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:07:00
